Methods and compositions for modulating morphogenic protein...

Details Methods and compositions for modulating morphogenic protein... Methods and compositions for modulating morphogenic protein...

C - Chemistry, Metallurgy

12

N

C12N 15/85 (2006.01) C07K 14/51 (2006.01) C12N 15/18 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2191583

Disclosed are methods and compositions for screening compounds for their ability to modulate expression of a tissue morphogenetic protein, particularly OP-1, OP-1 homologs and closely related proteins, using one or more OP-1-specific, noncoding nucleotide sequences and a suitable reporter gene.

Des procédés et des compositions servent à tester la capacité de composés de moduler l'expression d'une protéine morphogénétique des tissus, notamment la protéine ostéogénétique-1, les homologues de la protéine ostéogénétique-1 et les protéines qui lui sont étroitement apparentés, au moyen d'une ou plusieurs séquences de nucléotides non codants spécifiques de la protéine ostéogénétique-1 et d'un gène reporteur approprié.

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