C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/475 (2006.01) C12N 5/071 (2010.01) C12N 5/074 (2010.01) A61K 38/18 (2006.01) A61K 39/395 (2006.01) C07K 16/18 (2006.01) C12Q 1/02 (2006.01)
Patent
CA 2570407
The invention can be summarized as follows. There is provided methods and compositions for modulating proliferation and/or lineage commitment of stem cells by modulating the Wnt signalling pathways. Modulators of the Wnt signalling pathways and screening methods to identify modulators are also provided. The methods of the invention may be conducted in vitro or in vivo to induce or inhibit stem cell proliferation and/or lineage commitment, and are particularly useful for in vivo stimulation of proliferation and/or lineage commitment of resident stem cells in a tissue.
La présente invention concerne des procédés et compositions pour moduler la prolifération et/ou l'implication en lignées des cellules souches par modulation des chemins de signalisation Wnt. L'invention concerne également des modulateurs des chemins de signalisation Wnt et des procédés de recherche systématique de modulateurs. Les procédés de l'invention, qui peuvent être mis en oeuvre en procédures in vitro ou un vivo de façon à induire ou à inhiber la prolifération et/ou l'implication en lignées des cellules souches, conviennent particulièrement pour la stimulation in vivo de la prolifération et/ou de l'implication en lignées de cellules souches résidentes dans un tissu.
Fortin Anouk
Polesskaya Anna
Rudnicki Michael
Seale Patrick
Borden Ladner Gervais Llp
Ottawa Health Research Institute
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