A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01) A61K 38/17 (2006.01) A61K 38/21 (2006.01) C07K 16/28 (2006.01)
Patent
CA 2423436
This invention relates generally to the field of immunology or neuroimmunology. In particular, the invention provides a method for reducing or inhibiting T cell activation, which method comprises administering an effective amount of an antagonist of NCAM L1 to a mammal, wherein reduction or inhibition of T cell activation is desirable, thereby reducing or inhibiting T cell activation in said mammal. Combinations and combinatorial methods for modulating T cell activation are further provided. The invention also provides a method for potentiating T cell activation, which method comprises administering an effective amount of a multimerized neural cell adhesion molecule L1 (NCAM L1), or a functional derivative or fragment thereof, or a nucleic acid encoding said L1 or func tional derivative or fragment thereof, or an agent that enhances production and/or costimulatory function of said L1 to a mammal, wherein T cell activation is desirable, thereby potentiating T cell activation in said mammal.
L'invention concerne de façon générale le domaine de l'immunologie ou de la neuroimmunologie. Elle concerne, en particulier, un procédé servant à diminuer ou à inhiber l'activation des lymphocytes T et consistant à administrer une quantité efficace d'un antagoniste de NCAM L1 à un mammifère nécessitant la diminution ou l'inhibition de l'activation des lymphocytes T, ce qui permet de diminuer ou d'inhiber l'activation des lymphocytes T chez ledit mammifère. Elle concerne, de plus, des combinaisons et des procédés combinés servant à moduler l'activation des lymphocytes T. Elle concerne également un procédé servant à potentialiser l'activation des lymphocytes T et consistant à administrer une quantité efficace d'une molécule d'adhérence aux cellules neurales multimérisée L1 (NCAM L1) ou un de ses dérivés ou fragments fonctionnels, ou un acide nucléique codant L1 ou ledit dérivé fonctionnel ou ledit fragment, ou un agent amplifiant la production et/ou la fonction de stimulation combinée dudit L1 à un mammifère nécessitant l'activation des lymphocytes T, ce qui permet de potentialiser l'activation des lymphocytes T chez ledit mammifère.
Balaian Larissa
Montgomery Anthony
Fetherstonhaugh & Co.
Regents Of The University Of California
The Scripps Research Institute
LandOfFree
Methods and compositions for modulating t cell activation... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods and compositions for modulating t cell activation..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods and compositions for modulating t cell activation... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-2024647