Methods and compositions for modulating the immune system...

A - Human Necessities – 61 – K

Patent

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A61K 33/00 (2006.01) A61K 31/337 (2006.01) A61K 45/06 (2006.01)

Patent

CA 2468698

The present invention provides methods of preventing, treating or ameliorating one or more symptoms of disorders in which modulation of a subject's immune system is beneficial utilizing a lymphoid tissue inducing agent and an immunomodulatory agent. In particular, the present invention provides methods of preventing, treating or ameliorating a proliferative disorder, an infectious disease, a cardiovascular disease, an autoimmune disorder, or an inflammatory disorder or one or more symptoms thereof comprising administering to a subject in need thereof one or more lymphoid tissue inducing agents and one or immunomodulatory agents. The present invention also provides compositions and articles of manufacture for use in preventing, treating or ameliorating one or more symptoms associated with disorders in which modulation of a subject's immune system is beneficial, including, but not limited to proliferative disorders, infectious diseases, cardiovascular diseases, autoimmune disorders and inflammatory disorders. The present invention further provides methods for screening and identifying lymphoid tissue inducing agents and/or immunomodulatory agents.

L'invention concerne des méthodes permettant de prévenir, de traiter ou d'améliorer un ou plusieurs symptômes de troubles pour lesquels une modulation du système immunitaire du sujet est bénéfique, par l'administration d'un agent inducteur de tissu lymphoïde et d'un agent immunomodulateur. L'invention concerne en particulier des méthodes permettant la prévention, la traitement ou l'amélioration d'une pathologie proliférative, d'une maladie infectieuse, d'une maladie cardio-vasculaire, d'une maladie auto-immune, d'un trouble inflammatoire, ou d'un ou de plusieurs symptômes de ceux-ci. Cette méthode consiste à administrer à un sujet nécessitant un tel traitement, un ou plusieurs agents inducteurs de tissu lymphoïde et un ou plusieurs agents immunomodulateurs. L'invention concerne également des compositions et des articles fabriqués, destinés à prévenir, à traiter ou à améliorer un ou plusieurs symptômes associés à des troubles pour lesquels une modulation du système immunitaire est bénéfique, comprenant notamment, mais non exclusivement, les pathologies prolifératives, les maladies infectieuses, les maladies cardio-vasculaires, les troubles auto-immuns et les troubles inflammatoires. L'invention concerne en outre des procédés de criblage et d'identification d'agents inducteurs du tissu lymphoïde et/ou d'agents immunomodulateurs.

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