Methods and compositions for modulating tumor cell activity

Details Methods and compositions for modulating tumor cell activity Methods and compositions for modulating tumor cell activity

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 31/00 (2006.01) A61K 38/17 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C07K 16/18 (2006.01) C12N 15/12 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2621363

Antibodies which target clusterin, a protein involved in the epithelial-to- mesenchymal transition of carcinoma cells, are identified and characterized. The antibodies may be used to modulate tumour cell activity through binding to clusterin.

Selon l'invention, les anticorps qui ciblent la clusterine, une protéine jouant un rôle dans la transition épithéliale-à-mésenchymateuse (EMT) des cellules carcinomateuses, sont identifiés et caractérisés. Ces anticorps peuvent être utilisés pour moduler l'activité des cellules tumorales par une liaison à la clusterine.

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