C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/10 (2006.01) A61K 31/7088 (2006.01) A61K 39/00 (2006.01) A61K 45/00 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C12Q 1/02 (2006.01) C12Q 1/34 (2006.01) C12Q 1/48 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2496897
The invention provides methods and compositions for modulating the expression, processing, post-translational modification, and/or activity of XBP-1 protein, or a protein in a signal transduction pathway involving XBP-1. Exemplary XBP-1 activities that can be modulated using the methods and compositions of the invention include: the Unfolded Protein Response (UPR), plasma cell differentiation, immunoglobulin production, apoptosis and the production of IL- 6. The present invention also pertains to methods for identifying compounds that modulate the expression, processing, post-translational modification, and/or activity of XBP-1 protein or a molecule in a signal transduction pathway involving XBP-1.
L'invention concerne des procédés et des compositions permettant la modulation de l'expression, du traitement, de la modification post-translationnelle, et/ou de l'activité de la protéine XBP-1, ou d'une protéine dans un parcours de transduction de signal impliquant XBP-1. A titre d'exemple, on mentionne, comme activités XBP-1 pouvant être modulées au moyen des procédés et des compositions de l'invention : la réponse de la protéine dépliée (UPR), la différentiation cellule-plasma, la production d'immunoglobuline, l'apoptose et la production de IL-6. L'invention concerne également des procédés d'identification de composés modulant l'expression, le traitement, la modification post-translationnelle, et/ou l'activité de la protéine XBP-1 ou d'une molécule dans un parcours de transduction de signal impliquant XBP-1.
Glimcher Laurie H.
Iwakoshi Neil
Lee Ann-Hwee
Borden Ladner Gervais Llp
President And Fellows Of Harvard College
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