C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/02 (2006.01) A61K 39/395 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) G01N 33/566 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2118243
Processing of .beta.-amyloid precursor protein (.beta.APP) is monitored by detecting the secretion of a soluble bAPP fragment resulting from cleavage of .beta.APP at the amino-terminus of .beta.-amyloid peptide. in vivo monitoring of secretion of the .beta.APP fragment may be monitored for diagnosis and prognosis of Alzheimer's disease and other .beta.-amyloid-related diseases, while in vitro monitoring of such secretion from cultured cells may be monitored to identify inhibitors of .beta.-amyloid production. The .beta.APP fragment may be detected using antibodies and other specific binding substances which recognize a carboxy-terminal residue on the fragment.
Fritz Lawrence C.
Schenk Dale B.
Seubert Peter A.
Athena Neurosciences Inc.
Elan Pharmaceuticals Inc.
Eli Lilly And Company
Gowling Lafleur Henderson Llp
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