A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/44 (2006.01) A61K 39/395 (2006.01) C07K 16/00 (2006.01) C07K 16/46 (2006.01) C07K 19/00 (2006.01) C12N 1/00 (2006.01) C12N 1/21 (2006.01) C12P 21/00 (2006.01) C07K 14/195 (2006.01) C07K 14/21 (2006.01) C07K 14/705 (2006.01) C12N 5/10 (2006.01)
Patent
CA 2631952
The present invention relates, in part, to methods and compositions for needleless delivery of antibodies to a subject. The present invention also relates, in part, to methods for needleless delivery of fusion proteins comprising a bioactive molecule and an antibody fragment to subject. In one aspect, the methods and compositions involve administering to the subject a delivery construct comprising a carrier construct non-covalently bound to the antibody or fusion protein to be delivered, wherein the carrier construct comprises a receptor-binding domain, a transcytosis domain, and an antibody- binding domain to which the antibody or the antibody fragment of the fusion protein non-covalently binds.
La présente invention concerne, en partie, des procédés et des compositions d'apport sans aiguille d'anticorps à un individu. Cette invention porte également, en partie, sur des procédés d'apport sans aiguille de protéines hybrides comprenant une molécule bioactive et un fragment d'anticorps, à un individu. Selon un aspect, les procédés et les compositions impliquent d'administrer à l'individu, une construction d'apport comprenant une construction de vecteur liée de manière non covalente à l'anticorps ou à la protéine hybride devant être apportée, ladite structure de vecteur comprenant un domaine de liaison de récepteur, un domaine de transcytose et un domaine de liaison d'anticorps auquel se lie de manière non covalente l'anticorps ou le fragment d'anticorps de la protéine hybride.
Osler Hoskin & Harcourt Llp
Trinity Biosystems Inc.
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