A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/44 (2006.01) A61K 38/00 (2006.01) A61K 38/16 (2006.01) C07K 14/00 (2006.01) C07K 16/46 (2006.01) C12N 5/00 (2006.01)
Patent
CA 2631981
The present invention relates, in part, to methods and compositions for needleless delivery of macromolecules to a subject. In one aspect, the methods and compositions involve administering to the subject a delivery construct comprising a carrier construct non-covalently bound to a binding partner, wherein the carrier construct comprises a receptor-binding domain, a transcytosis domain, and a macromolecule to which the binding partner non- covalently binds, wherein the binding partner binds to the macromolecule with a Ka that is at least about 104 M-1.
La présente invention concerne en partie, des procédés et des compositions d'apport sans aiguille de macromolécules à un individu. Selon un aspect, les procédés et les compositions impliquent d'administrer à l'individu, une construction d'apport comprenant une construction de vecteur liée de manière non covalente à un partenaire de liaison, ladite structure de vecteur comprenant un domaine de liaison du récepteur, un domaine de transcytose et une macromolécule à laquelle se lie le partenaire de liaison de manière non covalente, ledit partenaire de liaison se liant à la macromolécule avec un Ka qui est au moins d'environ 104 M-1.
Osler Hoskin & Harcourt Llp
Trinity Biosystems Inc.
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