A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/48 (2006.01) A61K 49/14 (2006.01)
Patent
CA 2660373
Methods and compositions for needleless delivery of particles to the bloodstream of a subject are provided herein. In one aspect, the invention provides a delivery construct, comprising a receptor binding domain, a transcytosis domain, a particle to be delivered to a subject, and, optionally, a cleavable linker. In other aspects, the invention provides compositions comprising delivery constructs of the invention, kits comprising delivery constructs of the invention, and methods of using delivery constructs of the invention.
La présente invention concerne des procédés et des compositions permettant d'injecter, sans aiguille, des particules dans la circulation sanguine d'un sujet. Dans un aspect, l'invention concerne une construction d'injection, contenant un domaine de liaison avec un récepteur, un domaine de transcytose, une particule à injecter à un sujet, et, éventuellement, un lieur susceptible d'être clivé. Dans d'autres aspects, l'invention concerne des compositions contenant des constructions d'injection, des trousses contenant lesdites constructions d'injection, et des procédés d'utilisation desdites constructions d'injection.
Osler Hoskin & Harcourt Llp
Trinity Biosystems Inc.
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