A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/127 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C12N 15/88 (2006.01)
Patent
CA 2371922
The present invention relates to non-viral gene therapy methods and compositions for treatment of hyperproliferative disease in humans. More specifically, the invention is directed, in one embodiment, to lipid formulations which form stable liposome structures, capable of efficient in vivo nucleic acid transfer. In other embodiments, methods and compositions are directed to liposome transfer of anti-proliferative nucleic acids, wherein the transfer of the nucleic acids is cell specific via cell specific targeting moieties. The present invention, thus provides non-viral, liposome compositions and methods of gene transfer particularly useful for targeting and treating hyperproliferative disease.
La présente invention concerne des méthodes et des compositions de thérapie génique non-virale permettant de traiter les maladies hyperprolifératives chez l'humain. En particulier, l'invention concerne un mode de réalisation selon lequel des compositions lipidiques forment des structures liposomiques stables, capables de transférer, de manière efficace, l'acide nucléique in vivo. Dans d'autres modes de réalisation, des méthodes et des compositions permettent de transférer le liposome des acides nucléiques antiprolifératifs. Le transfert des acides nucléiques par le biais de fragments de ciblage spécifique aux cellules étant spécifique aux cellules. La présente invention concerne également des compositions liposomiques et non-virales ainsi que des méthodes de transfert de gènes particulièrement utiles pour cibler et traiter les maladies hyperprolifératives.
Ramesh Rajagopal
Roth Jack A.
Saeki Tomoyuki
Wilson Deborah
Board Of Regents The University Of Texas System
Goudreau Gage Dubuc
Introgen Therapeutics Inc.
P53 Inc.
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