Methods and compositions for nucleic acid delivery

Details Methods and compositions for nucleic acid delivery Methods and compositions for nucleic acid delivery

A - Human Necessities

61

K

A61K 48/00 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2425835

The present provides methods and compositions that enable effective delivery of nucleic to desired cells, including to a solid organ such as a mammalian heart. The methods and compositions enable effective gene transfer and subsequent expression to a majority of cells throughout a solid organ such as the heart. Methods and compositions of the invention preferably provide enhanced vascular permeability that enables increased gene transfer to targeted cells, but without significant degradation or injury to endothelial cell layers.

L'invention concerne des procédés et des compositions permettant de diffuser efficacement un acide nucléique aux cellules souhaitées et également à un organe solide comme un coeur de mammifère. Ces procédés et compositions permettent un transfert de gène efficace et l'expression subséquente d'une majorité de cellules dans un organe solide comme le coeur. Les procédés et compositions de la présente invention permettent d'obtenir une meilleure perméabilité vasculaire qui autorise un transfert de gène accru vers des cellules cibles, sans toutefois causer de dégradation ou de blessure importante aux couches cellulaires endothéliales.

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