Methods and compositions for oral administration of insulin

Details Methods and compositions for oral administration of insulin Methods and compositions for oral administration of insulin

A - Human Necessities

61

K

A61K 38/28 (2006.01) A61K 9/10 (2006.01) A61K 47/04 (2006.01) A61K 47/36 (2006.01) A61K 47/44 (2006.01) A61P 3/10 (2006.01)

Patent

CA 2711556

The present invention provides a pharmaceutical composition formulated for oral delivery of insulin, comprising a particulate non-covalently associated mixture of pharmacologically inert silica nanoparticles having a hydrophobic surface, a polysaccharide, and insulin suspended in an oil. The present invention further provides methods of manufacturing same and therapeutic methods utilizing same for oral delivery of insulin.

La présente invention concerne une composition pharmaceutique formulée pour une administration orale d'insuline, qui comprend un mélange particulaire, constitué de nanoparticules de silice associées de manière non covalente, inertes sur le plan pharmacologique, présentant une surface hydrophobe, un polysaccharide, et de l'insuline en suspension dans une huile. La présente invention concerne en outre des méthodes de préparation de ladite composition ainsi que des méthodes thérapeutiques dans lesquelles ladite composition est utilisée pour une administration orale d'insuline.

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