A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/10 (2006.01) A61K 47/04 (2006.01) A61K 47/36 (2006.01) A61K 47/44 (2006.01) A61K 38/16 (2006.01)
Patent
CA 2711554
The present invention provides a pharmaceutical composition formulated for oral delivery, comprising a particulate non-covalently associated mixture of pharmacologically inert silica nanoparticles having a hydrophobic surface, a polysaccharide, and a biologically active protein or peptide suspended in an oil. The present invention further provides methods of manufacturing same and therapeutic methods utilizing same for oral delivery of a therapeutic protein or peptide.
La présente invention concerne une composition pharmaceutique formulée pour une administration orale, qui comprend un mélange particulaire associé de manière non covalente de nanoparticules de silice inertes sur le plan pharmacologique présentant une surface hydrophobe, un polysaccharide, et une protéine ou peptide biologiquement actif en suspension dans une huile. La présente invention concerne en outre des méthodes de préparation de ladite composition ainsi que des méthodes thérapeutiques dans lesquelles ladite composition est utilisée pour une administration orale d'une protéine ou peptide thérapeutique.
Gribova Orna
Vol Alexander
Oshadi Drug Administration Ltd.
Ridout & Maybee Llp
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