Methods and compositions for passive immunotherapy

Details Methods and compositions for passive immunotherapy Methods and compositions for passive immunotherapy

A - Human Necessities

61

K

A61K 39/40 (2006.01) A61K 39/44 (2006.01) A61L 27/00 (2006.01) A61L 27/54 (2006.01) A61L 29/16 (2006.01) A61L 31/16 (2006.01) C07K 16/12 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2243557

The direct, concentrated local delivery of antibodies, and pooled human immunoglobulins in particular, to tissue surfaces (e.g., wounds, burns, etc.), and biomaterial implant surfaces significantly decreases the rate of infection at those sites and enhances healing. The immunoglobulins serve to opsonize circulating infectants for phagocytosis and killing, prior to microbial adhesion and biofilm formation, and neutralize bacterial toxins. The treatment methodology results in reduced inflammation, reduced complement and tissue damage, and reduced rejection of biomaterials and transplants.

L'administration locale, concentrée, directe d'anticorps, et notamment d'un pool d'immunoglobulines humaines, sur des surfaces tissulaires (telles que des plaies, des brûlures, etc.), et sur des surfaces d'implants de biomatériaux ralentit considérablement l'infection sur ces sites et améliore la cicatrisation. Les immunoglobulines servent à opsonizer les agents infectieux circulant en vue de favoriser leur phagocytose et leur élimination, avant adhésion microbienne et formation d'un biofilm, et de neutraliser les toxines bactériennes. Cette méthodologie de traitement entraîne une réduction des inflammations, du complément et des lésions tissulaires ainsi que du rejet des biomatériaux et des transplants.

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