Methods and compositions for peptide synthesis

Details Methods and compositions for peptide synthesis Methods and compositions for peptide synthesis

C - Chemistry, Metallurgy

07

K

C07K 14/16 (2006.01) C07K 1/06 (2006.01) C07K 7/04 (2006.01)

Patent

CA 2324348

The present invention relates, first, to methods for the synthesis of peptides, in particular T-20 (also referred to as "DP-178"; SEQ ID NO:1) and T-20-like peptides. Such methods utilize solid and liquid phase synthesis procedures to synthesize and combine groups of specific peptide fragments to yield the peptide of interest. The present invention further relates to individual peptide fragments which act as intermediates in the synthesis of the peptides of interest (e.g., T-20). The present invention still further relates to groups of such peptide intermediate fragments which can be utilized together to produce full length T- 20 and T-20-like peptides.

La présente invention concerne d'abord des méthodes de synthèse de peptides, notamment de peptides T-20 (également connus sous le nom de "DP-178"; SEQ ID NO 1) et de peptides similaires à T-20. Ces méthodes font appel à des procédés de synthèse en phase liquide et en phase solide pour faire la synthèse et combiner des groupes de fragments peptidiques spécifiques afin de produire le peptide voulu. La présente invention concerne également des fragments peptidiques individuels agissant comme intermédiaires dans la synthèse des peptides voulus (par exemple T-20). La présente invention concerne en outre des groupes de ces fragments peptidiques intermédiaires pouvant être utilisés ensemble pour produire des peptides T-20 et similaires à T-20, de pleine longueur.

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