Methods and compositions for peptide synthesis

Details Methods and compositions for peptide synthesis Methods and compositions for peptide synthesis

C - Chemistry, Metallurgy

07

K

C07K 14/435 (2006.01) C07K 5/00 (2006.01) C07K 7/00 (2006.01) C07K 14/16 (2006.01)

Patent

CA 2378086

The present invention relates, first, to methods for the synthesis of peptides referred to as T-1249 and T-1249-like peptides. Such methods utilize solid and liquid phase synthesis procedures to synthesize and combine groups of specific peptide fragments to yield the peptide of interest. The present invention further relates to individual peptide fragments which act as intermediates in the synthesis of the peptides on interest (e.g., T-1249). The present invention still further relates to groups of such peptide intermediate fragments which can be utilized together to produce full-length T-1249 and T- 1249-like peptides.

La présente invention concerne en premier lieu des méthodes pour la synthèse de peptides connus sous le nom de T-1249 et du type T-1249. Ces méthodes font appel à des procédés de synthèse en phase solide et en phase liquide pour faire la synthèse et combiner des groupes de fragments peptidiques spécifiques afin de produire le peptide voulu. La présente invention concerne également des fragments peptidiques individuels agissant comme intermédiaires dans la synthèse des peptides voulus (par exemple T-1249). La présente invention concerne en outre des groupes de ces fragments peptidiques intermédiaires pouvant être utilisés ensemble pour produire des peptides T-1249 et du type T-1249, de pleine longueur.

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