C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/09 (2006.01) C07H 21/02 (2006.01)
Patent
CA 2697055
An isolated double stranded ribonucleic acid (dsRNA) molecule that inhibits the expression of a target gene, the dsRNA comprising two strands of nucleotides wherein a first strand has a length of from 19 to 28 consecutive nucleotides and is substantially identical to a sequence in the target gene and wherein a second strand is substantially complementary to the first strand, and a binding moiety that binds a 3 ' end of the first strand to a 5 'end of the second strand. An isolated double stranded ribonucleic acid molecule comprising a first strand of nucleotides that is substantially identical to SEQ ID NO: 3 and a second strand that is substantially complementary to the first.
La présente invention concerne une molécule d'acide ribonucléique à double brin (dsRNA) isolé qui inhibe l'expression d'un gène cible, le dsRNA comprenant deux brins de nucléotides, un premier brin ayant une longueur comprise entre 19 et 28 nucléotides consécutifs et étant sensiblement identique à une séquence dans le gène cible et un second brin étant sensiblement complémentaire du premier brin, et une fraction de liaison liant une extrémité 3 ' du premier brin à une extrémité 5 ' du second brin. La présente invention concerne une molécule d'acide ribonucléique à double brin isolé comprenant un premier brin de nucléotides sensiblement identique à SEQ ID N° 3 et un second brin sensiblement complémentaire au premier.
Deeth Williams Wall Llp
Scott & White Healthcare
Scott And White Memorial Hospital And Scott Sherwood And Brindley Found Ation
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