Methods and compositions for predicting irinotecan toxicity

Details Methods and compositions for predicting irinotecan toxicity Methods and compositions for predicting irinotecan toxicity

C - Chemistry, Metallurgy

12

Q

C12Q 1/48 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2527320

The present invention concerns the methods and compositions for evaluating the risk of ironotecan toxicity in a cancer patient based on the genotype of the patient at position-3156 of the UGT1A1 gene or at any position in linkage disequilibrium with the -3156 variant.

La présente invention concerne des méthodes et des compositions permettant d'évaluer le risque de toxicité de l'irinotécan chez un patient atteint de cancer en fonction du génotype du patient au niveau de la position -3156 du gène <I>UGT1A1</I> ou au niveau de n'importe quelle position en déséquilibre de liaison avec le variant -3156.

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