A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 35/74 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/569 (2006.01)
Patent
CA 2232001
The invention provides methods and compositions for preventing and treating Clostridium difficile-associated disease in a subject, wherein the subject is either a human or a non-human animal. The method comprises administering to the subject an effective amount of a non-toxigenic strain of C. difficile or a combination of strains. A suitable non-toxigenic strain is selected from the M, T, C, P, S and AP group as defined by restriction endonuclease analysis. Also provided are pharmaceutical compositions and unit dosage forms comprising a single strain or a combination of strains selected from a non-toxigenic C. difficile group and a method for selecting non-toxigenic C. difficile strains.
L'invention concerne des procédés et des compositions pour prévenir et traiter les maladies associées à Clostridium difficile chez un sujet, humain ou animal. Le procédé consiste à administrer au sujet une quantité efficace d'une souche non toxicogène de C. difficile ou une combinaison de telles souches. Une souche non toxicogène appropriée est choisie dans les groupes M, T, C, P, S et AP, selon la classification basée sur l'analyse de l'endonucléase de restriction. L'invention concerne également des compositions pharmaceutiques et des doses unitaires comprenant une seule souche ou une combinaison de souches choisies dans un groupe non toxicogène de C. difficile, ainsi qu'un procédé pour sélectionner les souches non toxicogènes de C. difficile.
Gerding Dale N.
Gerding Dale N.
Torys Llp
LandOfFree
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