Methods and compositions for producing a cooling effect in...

A - Human Necessities – 61 – K

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A61K 31/08 (2006.01) A23G 3/00 (2006.01) A23L 1/03 (2006.01) A23L 1/226 (2006.01) A23L 2/52 (2006.01) A23L 2/56 (2006.01) A61F 7/00 (2006.01) A61K 9/02 (2006.01) A61K 9/08 (2006.01) A61K 9/107 (2006.01) A61K 9/20 (2006.01) A61K 47/08 (2006.01) C12G 3/04 (2006.01) A61K 9/00 (2006.01) A61K 9/12 (2006.01)

Patent

CA 2303094

A technique for the production of soothing and cooling sensations in tissues such as sensitive skin areas and mucous membranes is provided. To produce a sensation of esthetic cooling, dimethyl ether may be applied to the target tissues in the form of a liquid or a gas arising from a liquid that is sprayed, swallowed, or applied with a bandage or other dressing. Alternatively, it may be applied as a lozenge, suppository, or other solid dosage form that releases the dimethyl ether to the target tissue. The intensity and duration of the esthetic cooling effect is obtained when the dimethyl ether is applied at minute concentrations. It has also been discovered that this technique can enhance the perception of flavor of foods, beverages, and candies.

La présente invention concerne une technique permettant de produire des sensations de soulagement et de refroidissement dans des tissus tels que ceux des zones cutanées sensibles et des membranes des muqueuses. Pour produire une sensation de refroidissement appréciable, du diméthyléther peut être appliqué sur les tissus visés sous forme d'un liquide ou d'un gaz produit par un liquide vaporisé, avalé ou appliqué avec un bandage ou un pansement. L'application peut également se faire avec une pastille, un suppositoire ou une autre forme posologique solide qui libère le diméthyléther au niveau du tissu visé. L'intensité et la durée de l'effet de refroidissement appréciable est obtenu lorsque le diméthyléther est appliqué à des concentrations infimes. On a également découvert que cette technique peut améliorer la perception de la saveur des aliments, des boissons et des bonbons.

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