Methods and compositions for producing anti-androgenic effects

A - Human Necessities – 61 – K

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A61K 31/277 (2006.01) A61K 31/10 (2006.01) A61K 31/167 (2006.01)

Patent

CA 2655541

The invention refers to an oral bicalutamide-containing formulation with a modified release pattern. The composition is suitable for being administered in a twice-a-week, twice-a-week and once-a-week dosing schedule. The composition is used for producing an anti-androgenic effect.

L'invention propose un procédé et une composition pour produire un effet anti-androgène chez un mammifère. Le procédé comporte l'administration d'une composition pharmaceutique à libération modifiée de bicalutamide à un mammifère, avec une fréquence réduite d'administration des doses, pour le confort amélioré du patient et sa bonne observation du traitement. La composition de l'invention présente en outre une biodisponibilité supérieure et un profil pharmacocinétique amélioré par comparaison avec une composition de bicalutamide classique.

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