Methods and compositions for prostate epithelial cell...

A - Human Necessities – 61 – K

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A61K 38/48 (2006.01) A61K 38/18 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2504508

Methods and compositions for treating prostate cancer by promoting prostate epithelial cell differentiation are described. Treatment methods involve administration of an active form of prostate-derived factor (PDF), or of an inactive PDF precursor, or of a combination of a proprotein convertase (PC) with a PDF precursor, to increase the biological activity of PDF in the subject and promote prostate epithelial cell differentiation.

L'invention concerne des procédés et des compositions permettant de traiter le cancer de la prostate par stimulation de la différenciation des cellules épithéliales prostatiques. Ces procédés de traitement consistent, entre autres, à administrer une forme active du facteur dérivé de la prostate (PDF), un précurseur de PDF inactif ou une association d'une proprotéine convertase (PC) et d'un précurseur de PDF pour accroître l'activité biologique du PDF chez le sujet traité et favoriser la différenciation des cellules épithéliales prostatiques.

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