A - Human Necessities – 61 – F
Patent
A - Human Necessities
61
F
A61F 2/04 (2006.01) A61L 27/38 (2006.01) A61F 2/00 (2006.01) A61K 35/12 (2006.01) C12N 5/06 (2006.01)
Patent
CA 2395674
The invention is directed to compositions and methods of producing multilayered artificial organs comprising heterogenous polylayers. Polylayers comprising homogenous cell populations are created on one side of a biocompatible substrate such that a chimeric interface is produced between the heterogenous polylayers. Cellular interaction at the chimeric interface produce an interstitial biomaterial with morphological and functional characteristics that resemble the natural in vivo organ.
La présente invention concerne des compositions et des procédés de production d'organes artificiels multicouches contenant des multicouches hétérogènes. Les multicouches à base de populations de cellules homogènes sont créées sur un côté d'un substrat biocompatible de manière à obtenir l'interface chimère entre les multicouches hétérogènes. L'interaction cellulaire de l'interface chimère produit une biomatière interstitielle présentant des caractéristiques morphologiques et fonctionnelles similaires à l'organe naturel in vivo.
Children's Medical Center Corporation
Riches Mckenzie & Herbert Llp
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