A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/06 (2006.01) C07K 5/065 (2006.01) C07K 14/245 (2006.01) C12Q 1/02 (2006.01) C12Q 1/18 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2305528
The invention relates to methods and compositions for manipulating bacterial resistance to non-antibiotic antibacterial compositions, disinfectants and organic solvents. The invention provides methods for rendering bacterial cells susceptible to non-antibiotic antibacterial compositions. Also provided are methods to reduce the selection of bacterial mutants having a multiple antibiotic resistance phenotype by non-antibiotic antibacterial compositions. The invention also provides methods for testing the ability of non-antibiotic antibacterial compositions to select for or induce a multiple antibiotic resistance phenotype in bacteria. Also provided are methods for increasing or decreasing bacterial tolerance to organic solvents by increasing or decreasing the activity of bacterial organic solvent efflux pumps. Compositions useful in the foregoing methods are also provided.
L'invention concerne des méthodes et des compositions permettant de manipuler la résistance bactérienne de compositions antibactériennes non antibiotiques, de désinfectants et de solvants organiques; des méthodes permettant de rendre des cellules bactériennes sensibles à des compositions antibactériennes non antibiotiques; des méthodes permettant de diminuer la sélection de mutants bactériens présentant un phénotype de multirésistance aux antibiotiques à l'aide de compositions antibactériennes non antibiotiques; des méthodes permettant de tester la capacité de compositions antibactériennes non antibiotiques à sélectionner ou induire un phénotype de multirésistance aux antibiotiques dans les bactéries; des méthodes permettant d'augmenter ou de réduire la tolérance bactérienne des solvants organiques en augmentant ou réduisant l'activité des pompes d'écoulement des solvants organiques bactériens. Cette invention décrit également des compositions utiles pour les méthodes précitées.
Borden Ladner Gervais Llp
Trustees Of Tufts College
LandOfFree
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