Methods and compositions for reducing immune response

A - Human Necessities – 61 – K

Patent

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Details

A61K 35/16 (2006.01) A61K 35/76 (2006.01) A61K 48/00 (2006.01) A61M 1/34 (2006.01) A61M 1/36 (2006.01) B01J 20/32 (2006.01) C12N 7/02 (2006.01) C12N 15/861 (2006.01)

Patent

CA 2382138

The present invention provides an apparatus and method to diminish the pre- existing immune response to the administration of a therapeutic virus by the selective elimination of antiviral antibodies from the serum. The present invention provides a chromatographic material for the elimination of such antibodies. The invention further provides plasmapheresis apparatus comprising this material. The invention further provides methods for the employment of such apparatus as part of therapeutic treatment regiments.

La présente invention concerne un appareil et une technique permettant de diminuer la réponse immunitaire pré-existante de façon à administrer un virus thérapeutique par l'élimination sélective d'anticorps antiviraux du sérum. Cette invention concerne un matériau chromatographique destiné à l'élimination de ces anticorps. Cette invention concerne encore un appareil de plasmaphérèse comprenant ce matériau. Cette invention concerne enfin des techniques d'utilisation de ces appareils sous forme de traitements thérapeutiques.

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