Methods and compositions for reducing ischemia-derived...

A - Human Necessities – 61 – K

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A61K 38/00 (2006.01)

Patent

CA 2594436

Methods of decreasing the extent of occlusion in the lumen of a mammalian blood vessel due to an ischemic or other hypoxic event are provided. In one form, a method includes administering to a patient in need thereof a pharmaceutically effective amount of an inhibitor of .delta. protein kinase C, either alone or in combination with a second therapeutic agent, and wherein the blood vessel is a blood vessel of the microvasculature. Additionally, methods of decreasing endothelial cell swelling in a mammalian blood vessel due to an ischemic or other hypoxic event are also provided. In one form, a method includes administering to a patient in need thereof a pharmaceutically effective amount of an inhibitor of .delta. protein kinase C, either alone or in combination with a second therapeutic agent.

L'invention concerne des méthodes de réduction de l'extension de l'occlusion de la lumière d'un vaisseau sanguin, causée par un épisode ischémique ou hypoxique. Dans un mode de réalisation, la méthode consiste à administrer à un patient en ayant besoin une quantité efficace d'un point de vue pharmaceutique d'un inhibiteur de la d protéine kinase C, seul ou combiné à un second agent thérapeutique, le vaisseau sanguin étant un vaisseau sanguin microvasculaire. L'invention concerne, de plus, des méthodes de réduction du gonflement des cellules endothéliales dans un vaisseau sanguin causé par un épisode ischémique ou hypoxique. Dans un mode de réalisation, la méthode consiste à administrer à un patient en ayant besoin une quantité efficace d'un point de vue pharmaceutique d'un inhibiteur de la d protéine kinase C, seul ou combiné à un second agent thérapeutique.

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