A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/20 (2006.01) A61K 8/04 (2006.01) A61K 8/73 (2006.01) A61K 9/00 (2006.01) A61K 9/14 (2006.01) A61K 9/16 (2006.01) A61K 9/26 (2006.01) A61Q 11/00 (2006.01)
Patent
CA 2437375
The present invention provides methods and compositions for reducing the perception of poor-tasting pharmaceutically active agents in the oral cavity. The invention provides particles containing one or more pharmaceutically active agents, flavorants and cellulosic materials, as well as methods for making same and for incorporating same into pharmaceutical dosage forms. In certain embodiments, the particles have a diameter of up to about 1000 micrometers and include the pharmaceutically active agent, a flavorant, and at least one cellulosic material that is microcrystalline cellulose, microcrystalline cellulose coprocessed with a hydrocolloid, or any combination thereof, individually or in admixture with a hydrocolloid.
L'invention porte sur des procédés et des compositions réduisant la perception de principes actifs de goût désagréable par la cavité buccale, sur des particules contenant un ou plusieurs principes actifs, un arôme et un matériau cellulosique et sur leur procédé d'élaboration, et d'incorporation à des formes posologiques. Dans certaines variantes, les particules, d'un diamètre supérieur à environ 1000 µm, comportent un principe actif, un arôme et au moins un matériau de cellulose micro cristalline cocomprimé avec un hydrocolloïde, ou leur mélange seul ou ajouté à l'hydrocolloïde.
Erkoboni David F.
Favara Andrew J.
R.p. Scherer Technologies Inc.
Smart & Biggar
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