Methods and compositions for regulating biofilm development

Details Methods and compositions for regulating biofilm development Methods and compositions for regulating biofilm development

C - Chemistry, Metallurgy

12

N

C12N 1/00 (2006.01) A01N 51/00 (2006.01) A01N 59/00 (2006.01) A01P 1/00 (2006.01) A61K 31/195 (2006.01) A61K 33/00 (2006.01) A61L 2/16 (2006.01) A61P 31/00 (2006.01) C02F 1/50 (2006.01) C02F 1/68 (2006.01) C09K 15/20 (2006.01) C12N 1/04 (2006.01) C12N 1/20 (2006.01) C12N 1/38 (2006.01)

Patent

CA 2609378

The present invention relates to methods for promoting dispersal of, or preventing formation of microbial biofilms, comprising: exposing a biofilm to an effective amount of nitric oxide or at least one nitric oxide generating or releasing agent; treating a surface or medium susceptible to biofilm formation with an effective amount of nitric oxide or at least one nitric oxide generating or releasing agent; incorporating an effective amount of nitric oxide or at least one nitric oxide generating or releasing agent in a surface or medium susceptible to biofilm formation; or inducing the accumulation of one or more reactive oxygen or nitrogen species within microorganisms within said biofilm or capable of forming a biofilm. The invention also relates to methods for maintaining or enhancing or maintaining and enhancing the functioning of a biofilm, comprising exposing a biofilm to at least one nitric oxide scavenger, at least one antioxidant or at least one nitric oxide scavenger and at least one antioxidant. The invention also relates to compositions for promoting dispersal of, or preventing formation of microbial biofilms, or for maintaining or enhancing or maintaining and enhancing the functioning of microbial biofilms.

La présente invention concerne des méthodes permettant de promouvoir la dispersion ou d'éviter la formation de biofilms microbiens, consistant : à exposer un biofilm à une dose utile de monoxyde d'azote ou d'au moins un agent libérant ou produisant du monoxyde d'azote ; à traiter une surface ou un support sur lequel peut se former un biofilm avec une dose utile de monoxyde d'azote ou d'au moins un agent libérant ou produisant du monoxyde d'azote ; à introduire une dose utile de monoxyde d'azote ou d'au moins un agent libérant ou produisant du monoxyde d'azote dans une surface ou un support sur lequel peut se former un biofilm ; ou à induire une accumulation d'une ou plusieurs espèces réactives d'oxygène ou d'azote dans des micro-organismes contenus dans ledit biofilm ou capables de former un biofilm. L'invention concerne également des méthodes permettant de maintenir et/ou d'améliorer le fonctionnement d'un biofilm, consistant à exposer un biofilm à au moins un agent piégeur de monoxyde d'azote et/ou au moins un antioxydant.

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