Methods and compositions for regulating iron homeostasis by...

A - Human Necessities – 61 – K

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A61K 39/395 (2006.01) A61K 38/16 (2006.01) A61P 7/06 (2006.01)

Patent

CA 2742871

Modulation of iron homeostasis by regulating BMP-6 activity is provided. Methods of using BMP-6 and BMP-6 protein-specific reagents, such as antibodies, for altering serum iron levels in humans are provided. Such antibodies are useful in pharmaceutical compositions for the prevention and treatment of hemochromatosis and anemia of inflammation.

La présente invention concerne des procédés de modulation de l'homéostasie du fer par régulation de l'activité BMP-6, ainsi que des procédés visant à utiliser la protéine BMP-6 et des réactifs spécifiques de celle-ci, tels que des anticorps, pour modifier les niveaux sériques de fer chez les humains. Ces anticorps sont utiles dans des compositions pharmaceutiques destinées à la prévention et au traitement de l'hémochromatose et de l'anémie de l'inflammation.

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