A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/00 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61K 38/17 (2006.01) A61K 38/52 (2006.01) A61K 47/48 (2006.01) C07K 14/47 (2006.01)
Patent
CA 2371872
The invention relates to methods and compositions of WW-domains as phosphoserine and phosphothreonine binding modules. The WW-domain containing polypeptides of the invention can be used, for example, to regulate cell growth; to treat neurodegenerative diseases; to screen for substances that modulated interactions between WW-domain containing polypeptides and phosphorylated ligands; as drug targeting vehicles; to direct protein degradation; and in the treatment of certain diseases or conditions characterized by aberrant WW-domain containing polypeptides or their ligands.
L'invention concerne des techniques et des compositions ayant des domaines WW telles que des modules de fixation de phosphosérine et de phosphothréonine. Les polypeptides comprenant le domaine WW de l'invention peuvent être utilisés, par exemple, pour réguler la croissance cellulaire, pour traiter des maladie de la neurodégénérescence, pour rechercher des substances qui modulent les interactions entre des polypeptides comprenant le domaine WW et des ligands phosphorylés, comme vecteurs ciblant de médicament, pour diriger la dégradation protéique, et enfin pour traiter certaines maladies ou états caractérisés par des polypeptides comprenant le domaine WW ou leurs ligands aberrants
Lu Kun Ping
Zhou Xiao Zhen
Beth Israel Deaconess Medical Center
Borden Ladner Gervais Llp
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