Methods and compositions for regulation of cd28 expression

Details Methods and compositions for regulation of cd28 expression Methods and compositions for regulation of cd28 expression

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61K 31/70 (2006.01) A61K 31/711 (2006.01) A61K 35/12 (2006.01) A61K 48/00 (2006.01) A61P 37/02 (2006.01) C07H 21/00 (2006.01) C12N 5/08 (2006.01) C12N 15/09 (2006.01)

Patent

CA 2211621

Oligomers are provided which are capable of reducing CD28 gene in a T cell. In addition to specific sequences, the invention includes a class of oligomers having at least two sequences of GGGG separated by 3 to 5 bases. Targets include CD28 gene, 5' untranslated regions and initiation codon, and their respective transcripts. Methods include use of the oligomers to moderate the pathogenic effects on the immune system in immune system-mediated diseases including graft versus host disease, septic shock syndrome, viral diseases, psoriasis, Type I (insulin-dependent) diabetes mellitus, thyroiditis, sarcoidosis, multiple sclerosis, autoimmune uveitis, rheumatoid arthritis, systemic lupus erythematosus and inflammatory bowel disease.

L'invention concerne des oligomères capables de réduire l'expression du gène CD28 dans un lymphocyte T. Outre des séquences spécifiques, l'invention concerne une classe d'oligomères comprenant au moins deux séquences de GGGG séparées par 3 à 5 bases. Les cibles sont, entre autres, le gène CD28, les régions 5' non traduites et le codon d'initiation et leurs produits de transcription respectifs. Les méthodes englobent l'utilisation d'oligomères pour modérer les effets pathogènes sur le système immunitaire dans des maladies induites par le système immunitaire, dont la réaction du greffon contre l'hôte, le choc septique, les maladies virales, le psoriasis, le diabète sucré (insulino-dépendant) du Type I, la thyroïdite, la sarcoïdose, la sclérose en plaques, l'uvïte auto-immune, la polyarthrite rhumatoïde, le lupus érythémateux aigu dissimulé et l'affection abdominale inflammatoire.

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