Methods and compositions for rna interference

Details Methods and compositions for rna interference Methods and compositions for rna interference

C - Chemistry, Metallurgy

07

H

C07H 21/02 (2006.01) A01K 67/027 (2006.01) A61K 31/7088 (2006.01) A61K 31/7105 (2006.01) A61K 31/713 (2006.01) A61K 35/12 (2006.01) C12N 15/11 (2006.01) C12N 15/85 (2006.01) C12P 19/34 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2473944

The present invention provides methods for attenuating gene expression in a cell using gene-targeted double stranded RNA (dsRNA). The dsRNA contains a nucleotide sequence that hybridizes under physiologic conditions of the cell to the nucleotide sequence of at least a portion of the gene to be inhibited (the "target" gene).

La présente invention concerne des méthodes d'atténuation de l'expression génétique dans une cellule au moyen d'un ARN bicaténaire (ARNds) à ciblage génique. L'ARNds contient une séquence nucléotidique s'hybridant dans des conditions physiologiques de la cellule à la séquence nucléotidique d'au moins une partie du gène à inhiber (le gène "cible").

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