Methods and compositions for rna interference

Details Methods and compositions for rna interference Methods and compositions for rna interference

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61K 31/7105 (2006.01) C12N 15/10 (2006.01) C12N 15/63 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2403397

The present invention provides methods for attenuating gene expression in a cell using gene-targeted double stranded RNA (dsRNA). The dsRNA contains a nucleotide sequence that hybridizes under physiologic conditions of the cell to the nucleotide sequence of at least a portion of the gene to be inhibited (the "target" gene).

L'invention concerne des procédés servant à atténuer l'expression d'un gène dans une cellule au moyen d'un ARN bicaténaire (ARNds) dirigé vers un gène ciblé. Cet ARNdn contient une séquence de nucléotides s'hybridant dans des conditions physiologiques de la cellule, à la séquence de nucléotides d'au moins une partie du gène à inhiber (le gène "ciblé").

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