C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/705 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2206110
Methods and compositions related to the identification of compounds that block neurotransmitter release are disclosed. Using the methods of the present invention, candidate compounds may be screened for the ability to bind to presynaptic calcium channels such that the docking of presynaptic vesicles to presynaptic calcium channels will be inhibited. The present invention also discloses peptides useful in the screening methods.
L'invention concerne des procédés et des compositions associés à l'identification de composés bloquant la libération de neurotransmetteurs. Les procédés présentés permettent de cribler des composés candidats en fonction de leur aptitude à se fixer aux canaux calciques présynaptiques de sorte que l'amarrage de vésicules présynaptiques aux canaux calciques présynaptiques soit inhibé. La présente invention concerne également des peptides pouvant être utilisés dans les procédés de criblage présentés.
Catterall William A.
Sheng Zu-Hang
Gowling Lafleur Henderson Llp
University Of Washington
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