C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/48 (2006.01) A61K 45/08 (2006.01) C12N 9/12 (2006.01) G01N 33/542 (2006.01) G01N 33/566 (2006.01) G01N 33/573 (2006.01) G01N 33/60 (2006.01) G01N 33/92 (2006.01)
Patent
CA 2423889
The present invention relates to methods of screening compounds that modulate lipid kinases activity. The invention is more preferably based on the SPA technology to screen compounds that modulate the activity of lipid kinases, in particular membrane lipid kinases, more specifically sphingosine kinases. The invention also includes compositions, products, kits, etc. for use in performing the above methods, as well as the compounds identified by said methods, and their uses.
L'invention porte sur des procédés de criblage de composés modulateurs de l'activité de kinases lipidiques et de préférence sur la technique SPA de criblage de composés modulateurs de l'activité de kinases lipidiques, en particulier de kinases lipidiques membranaires, et plus spécifiquement de sphingosine kinases. L'invention porte également sur des compositions, produits, trousses, etc. servant à la mise en oeuvre de ces techniques, et sur les composés ainsi identifiée et leurs utilisations.
Casamitjana Olivier
Melendez Alirio
Moreau Francois
Normant Emmanuel
Robic
Warner-Lambert Company Llc
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