Methods and compositions for selectively removing potassium...

A - Human Necessities – 61 – K

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Details

A61K 31/75 (2006.01) A61K 9/16 (2006.01) A61K 9/50 (2006.01) A61K 31/785 (2006.01) A61P 3/12 (2006.01)

Patent

CA 2624170

The present invention provides methods and compositions for the treatment of ion imbalances using core-shell composites and compositions comprising such core-shell composites. In particular, the invention provides core-shell particles and compositions comprising potassium binding polymers, and core- shell particles and compositions comprising sodium binding polymers, and in each case, pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are also disclosed. The compositions and methods of the invention offer improved approaches for treatment of hyperkalemia and other indications related to potassium ion homeostasis, and for treatment of hypertension and other indicates related to sodium ion homeostasis.

La présente invention concerne des méthodes et des compositions destinées au traitement de déséquilibres ioniques, dans lesquelles sont utilisés des composites noyau-enveloppe et des compositions comprenant ces composites noyau-enveloppe. L'invention concerne plus précisément des particules noyau-enveloppe et des compositions comprenant des polymères fixant le potassium, ainsi que des particules noyau-enveloppe et des compositions comprenant des polymères fixant le sodium, et, dans chaque cas, des compositions pharmaceutiques comprenant ces particules et ces compositions. L'invention concerne également des méthodes destinées à l'utilisation de ces compositions polymériques et pharmaceutiques à des fins thérapeutiques et/ou préventives. Les compositions et les méthodes de l'invention offrent de meilleures approches pour le traitement de l'hyperkaliémie et d'autres indications en rapport avec l'homéostasie des ions potassium, et pour le traitement de l'hypertension et d'autres indications en rapport avec l'homéostasie des ions sodium.

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