C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) A61K 31/44 (2006.01) A61K 31/47 (2006.01) A61K 45/06 (2006.01) C07H 21/02 (2006.01) C07H 21/04 (2006.01) C12N 9/14 (2006.01) C12N 9/84 (2006.01) C12N 9/86 (2006.01) C12N 15/10 (2006.01) C12P 21/06 (2006.01) C12Q 1/00 (2006.01) C12Q 1/08 (2006.01) C12Q 1/34 (2006.01) C12Q 1/70 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/554 (2006.01)
Patent
CA 2266978
The invention provides for methods and compositions for identifying proteins or chemicals that directly or indirectly modulate a genomic polynucleotide and methods for identifying active genomic polynucleotides. Generally, the method comprises inserting a BL (beta-lactamase) expression construct into an eukaryotic genome, usually non- yeast, contained in at least one living cell, contacting the cell with a predetermined concentration of a modulator, and detecting BL. activity in the cell.
L'invention concerne des procédés et des compositions pour l'identification de protéines ou de substances chimiques qui modulent directement ou indirectement un polynucléotide génomique, ainsi que des procédés d'identification de polynucléotides génomiques actifs. D'une manière générale, le procédé consiste à insérer une construction d'expression de BL (bêta-lactamase) dans un génome eucaryote, habituellement non levure, contenu dans au moins une cellule vivante, à mettre ladite cellule en contact avec une concentration prédéterminée d'un modulateur et à détecter l'activité de BL dans la cellule.
Craig Frank
Foulkes Gordon J.
Mere Lora
Negulescu Paul A.
Whitney Michael A.
Aurora Biosciences Corporation
Mbm Intellectual Property Law Llp
Vertex Pharmaceuticals (san Diego) Llc
LandOfFree
Methods and compositions for sensitive and rapid, functional... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods and compositions for sensitive and rapid, functional..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods and compositions for sensitive and rapid, functional... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1385423