C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) A01K 67/00 (2006.01) C12N 15/10 (2006.01) C12Q 1/34 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2409901
The invention provides for a methods and compositions for identifying proteins or compounds that directly or indirectly modulate a genomic polynucleotide and methods for identifying active genomic polynucleotides. Generally, the method comprises inserting a BL (beta-lactamase) expression construct into an eukaryotic genome, usually non-yeast, contained in at least one living cell, contacting the cell with a predetermined concentration of a modulator, and detecting BL activity in the cell.
Craig Frank
Foulkes Gordon J.
Mere Lora
Negulescu Paul A.
Whitney Michael A.
Aurora Biosciences Corporation
Mbm Intellectual Property Law Llp
Vertex Pharmaceuticals (san Diego) Llc
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