Methods and compositions for sleep disorders and other...

A - Human Necessities – 61 – K

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A61K 31/4985 (2006.01) A61K 31/5383 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2725342

Use of particular substituted heterocycle fused gamma-carboline compounds as pharmaceuticals and pharmaceutical compositions comprising them for the treatment of one or more disorders involving the 5-HT2A, SERT and/or dopamine D2 pathways are disclosed. In addition, the compounds may be combined with other therapeutic agents for the treatment of one or more sleep disorders, depression, psychosis, dyskinesias, and/or Parkinson's disease or any combinations.

L'invention porte sur l'utilisation de composés gamma-carboline fusionnés hétérocycles substitués particuliers en tant que produits pharmaceutiques et compositions pharmaceutiques les renfermant pour le traitement d'un ou plusieurs troubles mettant en jeu les voies de 5-HT2A, SERT et/ou dopamine D2. De plus, les composés peuvent être combinés avec d'autres agents thérapeutiques pour le traitement d'un ou plusieurs troubles du sommeil, de la dépression, d'une psychose, d'une dyskinésie et/ou de la maladie de Parkinson ou toutes combinaisons.

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