Methods and compositions for specific modulation of mcl-1

Details Methods and compositions for specific modulation of mcl-1 Methods and compositions for specific modulation of mcl-1

C - Chemistry, Metallurgy

07

K

C07K 14/47 (2006.01) A61K 38/17 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2746256

A series of stapled BCL-2 family peptide helices were identified as able to target the survival protein MCL-I with high affinity and a subset with unprecedented selectivity. Agents and methods for selective pharmacologic neutralization of MCL-I are provided for drug discovery and therapeutic uses, including use in overcoming the apoptotic resistance of cancer and other diseases associated with impaired cell death.

L'invention concerne une série d'hélices peptidiques agrafées de la famille BCL-2, qui ont été identifiées comme étant capables de cibler la protéine de survie MCL-I avec une grande affinité et un sous-ensemble avec une sélectivité sans précédent. L'invention concerne également des agents et des procédés permettant la neutralisation pharmacologique sélective de MCL-I pour la découverte de médicaments et d'utilisations thérapeutiques, y compris l'utilisation pour surmonter la résistance apoptotique du cancer et d'autres maladies associées à une mort cellulaire altérée.

Affiliated with

Also associated with

Rating

Methods and compositions for specific modulation of mcl-1 does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods and compositions for specific modulation of mcl-1, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods and compositions for specific modulation of mcl-1 will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1448544