Methods and compositions for stimulating bone cells

Details Methods and compositions for stimulating bone cells Methods and compositions for stimulating bone cells

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 31/70 (2006.01) A61K 38/29 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) A61K 49/00 (2006.01) A61K 51/06 (2006.01) C07K 14/47 (2006.01) C07K 14/51 (2006.01) C07K 14/635 (2006.01) C07K 14/72 (2006.01) C07K 14/78 (2006.01) C12N 5/10 (2006.01) C12N 15/85 (2006.01) C12N 15/87 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2183542

Disclosed are methods, compositions, kits and devices for use in transferring nucleic acids into bone cells in situ and/or for stimulating bone progenitor cells. Type II collagen and, particularly, osteotropic genes, are shown to stimulate bone progenitor cells and to promote bone growth, repair and regeneration in vivo. Gene transfer protocols are disclosed for use in transferring various nucleic acid materials into bone, as may be used in treating various bone-related diseases and defects including fractures, osteoporosis, osteogenesis, imperfecta and in connection with bone implants.

On décrit des procédés, compositions, trousses et dispositifs utilisés pour transférer des acides nucléiques dans des cellules osseuses in situ et/ou pour stimuler les cellules mères osseuses. On constate que le collagène de type II, et en particulier les gènes ostéotropes, stimulent les cellules mères osseuses et promeuvent la croissance, la réparation et la régénération osseuses in vivo. On décrit des protocoles de transferts géniques utiles pour le transfert dans les os de substances à base de divers acides nucléiques, substances permettant de traiter différents défauts et maladies osseux, y compris des fractures, l'ostéoporose et les fragilités osseuses héréditaires, et s'utilisant aussi pour les implants osseux.

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