A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 35/12 (2006.01) C12N 5/071 (2010.01) C12N 5/079 (2010.01) A61K 31/437 (2006.01) A61K 31/44 (2006.01) A61P 25/00 (2006.01)
Patent
CA 2688327
The invention provides compositions and methods for treating, preventing, delaying the onset, and/or delaying the development of a disease or condition for which the activation, differentiation, and/or proliferation of one or more cell types is beneficial. These compositions and methods include, for example, a hydrogenated pyrido [4,3 -b] indole such as dimebon and/or a cell that has been incubated with a hydrogenated pyrido [4,3 -b] indole such as dimebon. In some embodiments, the compositions and methods also include a growth factor and/or an anti-cell death compound. The invention also provides methods of activating a cell, promoting the differentiation of a cell, and/or promoting the proliferation of a cell by incubating the cell with one or more hydrogenated pyrido [4,3 -b] indoles or pharmaceutically acceptable salts thereof. In some embodiments, the cell is also incubated with one or more growth factors and/or anti-cell death compounds.
L'invention concerne des compositions et procédés pour traiter, prévenir, retarder le départ et/ou retarder le développement d'une maladie ou affection pour l'activation, la différenciation et/ou la prolifération d'un ou plusieurs types de cellules sont bénéfiques. Ces compositions et procédés comprennent, par exemple, un pyrido[4,3-b] indole hydrogéné tel que le dimébon et/ou une cellule incubée avec un pyrido[4,3-b] indole hydrogéné tel que le dimébon. Dans certains modes de réalisation, les compositions et procédés comprennent également un facteur de croissance et/ou un composé anti-mort cellulaire. L'invention concerne également des procédés d'activation d'une cellule, de promotion de la différenciation d'une cellule et/ou de promotion de la prolifération d'une cellule par incubation de la cellule avec un ou plusieurs pyrido[4,3-b] indoles hydrogénés ou des sels pharmaceutiquement acceptables de ceux-ci. Dans certains modes de réalisation, la cellule est également incubée avec un ou plusieurs facteurs de croissance et/ou des composés anti-mort cellulaire.
Hung David T.
Protter Andrew Asher
Borden Ladner Gervais Llp
Medivation Neurology Inc.
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