Methods and compositions for suppressing an immune response...

C - Chemistry – Metallurgy – 07 – K

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C07K 14/74 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61K 38/17 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2230119

Methods and compositions for suppressing an immune response using or comprising peptide fragments of the alpha chain of class II major histocompatibility complex containing a highly conserved motif and effective to suppress at least one and preferably all of the following: a mixed lymphocyte reaction or other T-cell allorecognition reaction; generation of cytotoxic T-cells recognizing an alloantigen; lymphocyte proliferation against tissue antigen; and stimulatory cytokine production by lymphocytes. Immune responses that can be abated or suppressed include alloimmunity and autoimmunity.

L'invention se rapporte à des procédés et à des compositions permettant de supprimer une réponse immune mettant en oeuvre ou comprenant des fragments peptidiques de la chaîne alpha du complexe majeur d'histocompatibilité de la classe II, ces fragments peptidiques contenant un motif extrêmement bien conservé et efficace pour supprimer un et de préférence tous les phénomènes suivants: une réaction lymphocitaire mixte ou d'autres réactions d'alloreconnaissance des lymphocytes T; la génération des lymphocytes T cytotoxiques reconnaissant un alloantigène; la prolifération lymphocitaire contre l'antigène tissulaire; et la production de cytokine stimulatrice par des lymphocytes. Les réponses immunes qui peuvent être atténuées ou déprimées sont l'alloimmunité et l'autoimmunité.

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