C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/53 (2006.01) A23D 9/00 (2006.01) A23K 1/00 (2006.01) A23K 1/16 (2006.01) A23L 1/29 (2006.01) A23L 1/30 (2006.01) A61K 31/20 (2006.01) A61K 31/202 (2006.01) C11B 1/00 (2006.01) C12N 5/10 (2006.01) C12N 9/02 (2006.01) C12N 15/81 (2006.01) C12N 15/82 (2006.01) C12N 15/83 (2006.01) C12P 7/64 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2286263
The present invention relates to a fatty acid .DELTA.5-desaturase able to catalyze the conversion of dihomo-gamma-linolenic acid to arachidonic acid. Nucleic acid sequences encoding .DELTA.5-desaturase, nucleic acid sequences which hybridize thereto, DNA constructs comprising a .DELTA.5-desaturase gene, and recombinant host microorganism or animal expressing increased levels of a .DELTA.5-desaturase are described. Methods for desaturating a fatty acid at the .DELTA.5 position and for producing arachidonic acid by expressing increased levels of a .DELTA.5-desaturase are disclosed. Fatty acids, and oils containing them, which have been desaturated by a .DELTA.5-desaturase produced by recombinant host microorganisms or animals are provided. Pharmaceutical compositions, infant formulas or dietary supplements containing fatty acids which have been desaturated by a .DELTA.5-desaturase produced by a recombinant host microorganism or animal also are described.
L'invention concerne une .DELTA.5-désaturase d'acide gras capable de ou catalyser la conversion de l'acide dihomo-gamma-linoléique en acide arachidonique. L'invention porte aussi sur des séquences nucléotidiques codant une .DELTA.5-désaturase, sur des séquences nucléotidiques s'hybridant à celle-ci, des produits de reconstruction d'ADN comprenant un gène de .DELTA.5-désaturase, et un animal ou un micro-organisme hôte recombiné, exprimant des taux élevés de .DELTA.5-désaturase. Elle se rapporte aussi à des procédés de désaturation d'un acide gras en position .DELTA.5 et de production d'acide arachidonique par l'expression de taux accrus d'une .DELTA.5 désaturase. Des acides gras et des huiles les contenant, ayant été désaturés par une .DELTA.5-désaturase produite par des animaux ou des micro-organismes hôtes recombinés sont décrits, ainsi que des compositions pharmaceutiques, des préparations pour nourrissons ou des compléments alimentaires contenant des acides gras ayant été désaturés par une .DELTA.5-désaturase produite par un animal ou un micro-organisme hôte recombiné.
Chaudhary Sunita
Huang Yung-Sheng
Knutzon Deborah
Leonard Amanda Eun-Yeong
Mukerji Pradip
Abbott Laboratories
Calgene Llc
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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