Methods and compositions for targeting a cell

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/62 (2006.01) A61K 48/00 (2006.01) C07K 14/16 (2006.01) C07K 14/475 (2006.01) C07K 14/49 (2006.01) C07K 14/52 (2006.01) C07K 19/00 (2006.01) C12N 7/01 (2006.01) C12N 15/10 (2006.01) C12N 15/12 (2006.01) C12N 15/86 (2006.01) C12N 15/867 (2006.01) C12Q 1/70 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2386824

Oligomeric ligands, such as cysteine knot growth factors, can be displayed on the surface of viral particles as recombinant fusion proteins. The recombinant fusion proteins can be used to screen for drugs which will inhibit binding of an oligomeric ligand to its receptor and for targeting transferable labels, including therapeutic gene products, to cells bearing a receptor specific for the oligomeric ligand.

L'invention porte sur des ligands oligomères, tels que des facteurs de croissance de noeuds de cystéine, pouvant se présenter sur la surface de particules polymères sous forme de protéines de fusion de recombinaison. Ces protéines de fusion de recombinaison peuvent être utilisées dans le criblage de médicaments pour inhiber la liaison d'un ligand oligomère à son récepteur et pour cibler des étiquettes transférables, y compris des produits géniques thérapeutiques, sur des cellules supportant un récepteur spécifique du ligand oligomère.

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