C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) A01N 25/00 (2006.01) A01N 43/04 (2006.01) A61K 38/00 (2006.01) C07G 3/00 (2006.01) C07K 1/00 (2006.01) C12N 9/14 (2006.01) C12N 15/12 (2006.01) C12Q 1/34 (2006.01) C12Q 1/42 (2006.01) C12Q 1/48 (2006.01)
Patent
CA 2308637
Protein targets for disease intervention through inhibition of nucleic acid metabolism are disclosed. Novel polypeptides for one such target, DNA- dependent ATPase A, and novel polynucleotides encoding DNA-dependent ATPase A are disclosed. Phosphoaminoglycoside compounds which act on such protein targets to inhibit nucleic acid metabolism. In addition, screening assays for identifying compounds that inhibit nucleic acid-dependent ATPase activity, including, but not limited to, DNA-dependent ATPase A, are disclosed. Such compounds are useful in the treatment of diseases, including but not limited to cancer and infectious disease, through disruption of nucleic acid metabolism and induction of apoptosis. Moreover, methods for prevention and treatment of diseases including, but not limited to cancer and infectious disease are disclosed.
L'invention concerne des cibles protéiniques destinées à la prévention de maladies par l'inhibition du métabolisme des acides nucléiques. Elle a pour objet ce qui suit de nouveaux polypeptides pour l'une de ces cibles, à savoir l'ATPase A dépendante des ADN, et de nouveaux polynucléotides codant pour l'ATPase A dépendante des ADN; des composés à base de phospho-aminoglucosides agissant sur ces protéines cibles de manière à inhiber le métabolisme des acides nucléiques; et des méthodes de criblage pour identifier les composés qui inhibent l'activité de l'ATPase dépendante des ADN, y compris mais non de façon exclusive l'ATPase A dépendante des ADN. Ces composés sont utiles dans le traitement de maladies, y compris mais non de façon exclusive le cancer et les maladies infectieuses, et ce par l'interruption du métabolisme des acides nucléiques et l'induction de l'apoptose. En outre, l'invention a pour objet des procédés de prévention et de traitement de maladies, y compris mais non de façon exclusive le cancer et les maladies infectieuses.
Hockensmith Joel W.
Muthuswami Rohini
Osler Hoskin & Harcourt Llp
The University Of Virginia Patent Foundation
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