Methods and compositions for the detection and treatment of...

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/68 (2006.01)

Patent

CA 2646269

The present invention relates to methods and compositions for the detection and treatment of melanoma and skin cancers. More particularly, the invention discloses that BCSC-1 expression is altered in melanoma and skin cancer cells, allowing the design of effective detection methods and kits for such conditions. The invention also shows that restoring or increasing expression of BCSC-1 in melanoma and skin cancer cells suppresses tumorigenicity and represents a novel and effective approach for the treatment of melanoma and skin cancers. The invention may be used to detect the presence, stage or type of melanoma and skin cancers, as well as any predisposition thereto. The invention may be used in any mammalian subject, particularly human subjects.

La présente invention concerne des procédés et des compositions destinés à la détection et au traitement de mélanomes et de cancers de la peau. L'invention dévoile plus particulièrement le fait que l'expression BCSC-1 est diminuée dans les cellules de mélanomes et de cancers de la peau, permettant ainsi la conception de procédés de détection efficaces et de kits de détection de tels affections. L'invention montre également que la restauration ou l'accroissement de l'expression de BCSC-1 dans les cellules de mélanomes et de cancers de la peau supprime l'activité tumorigène et constitue une nouvelle approche efficace du traitement des mélanomes et des cancers de la peau. L'invention peut également être utilisée pour détecter la présence, le stade ou le type de mélanome et de cancer de la peau, ainsi que toute prédisposition. L'invention peut être utilisée chez tout sujet mammifère, notamment les sujets humains.

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