Methods and compositions for the detection of cervical cancer

Details Methods and compositions for the detection of cervical cancer Methods and compositions for the detection of cervical cancer

G - Physics

01

N

G01N 33/574 (2006.01) A61K 31/70 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2263888

The invention provides a wide range of methods and compositions for detecting and treating cervical cancer in an individual. Specifically, the invention provides target cervical cancer-associated proteins, which permit a rapid detection, preferably before metastases occur, of cervical cancer. The target cervical cancer-associated protein, may be detected, for example, by reacting the sample with a labeled binding moiety, for example, a labeled antibody capable of binding specifically to the protein. The invention also provides kits useful in the detection of cervical cancer in an individual. In addition, the invention provides methods utilizing the cervical cancer-associated proteins either as targets for treating cervical cancer or as indicators for monitoring of the efficacy of such a treatment.

L'invention concerne une gamme importante de procédés et de compositions servant à détecter et à traiter le cancer du col de l'utérus chez la femme. Elle concerne, particulièrement, des protéines cibles associés au cancer du col de l'utérus et permettant une détection rapide, de préférence, avant l'apparition des métastases, du cancer du col de l'utérus. On peut détecter cette protéine, par exemple, en effectuant la réaction du spécimen avec une fraction de fixation marquée, par exemple, un anticorps marqué capable de se fixer de façon spécifique à la protéine. Elle concerne également des trousses utiles pour détecter le cancer du col de l'utérus. Elle concerne, de plus, des procédés mettant en application ces protéines, soit en tant que cibles servant à traiter le cancer du col de l'utérus, soit en tant qu'indicateurs servant à contrôler l'efficacité de ce type de traitement.

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