Methods and compositions for the diagnosis and therapy of...

Details Methods and compositions for the diagnosis and therapy of... Methods and compositions for the diagnosis and therapy of...

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) A61K 31/70 (2006.01) A61K 38/17 (2006.01) A61K 39/00 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C07K 14/47 (2006.01) C07K 16/30 (2006.01) C12N 15/11 (2006.01) G01N 33/574 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2344563

Methods and compositions for the diagnosis and therapy of prostate cancer are described. The methods of the invention utilize isolated polynucleotides corresponding to the human Y-specific gene TSPY (testis-specific protein Y- encoded) (Arnemann, J et al., 1991, Genomics 11: 108-114), proteins encoded by the TSPY gene and fragments thereof, and antibodies capable of specifically recognizing and binding to TSPY proteins.

L'invention concerne des procédés et des compositions pour le diagnostic et la thérapie du cancer de la prostate. Les procédés considérés reposent sur l'utilisation de polynucléotides isolés correspondant au gène humain Y-spécifique TSPY (protéine à codage Y spécifique du testicule) (Arnemann, J et autres, 1991, Genomics 11: 108-114), de protéines codées par le gène TSPY et de fragments de ces protéines, et d'anticorps capables de reconnaître spécifiquement les protéines TSPY et de se lier avec elles.

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